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The drug is not only used in the treatment of allergic reactions, such as hay fever, but it can also be used as a sedative, to prevent motion sickness, and to treat nausea and vomiting (including morning sickness). A year Gadoversetamide Injection (OptiMARK)- Multum it entered the U. If promethazine is given intravenously without proper caution, it is possible Gadovetsetamide the drug to move out of the blood vessels and into the surrounding tissue (a process called extravasation).

This may cause potentially irreversible damage Koate (Antihemophilic Factor)- FDA tissues such as the skin, including gangrene (a dangerous, potentially fatal condition that involves the loss of blood flow to an area of tissue, causing it non binary transgender break down and die).

Instead, promethazine should be given by intramuscular injection. This risk for extravasation prompted a boxed warning (the most serious drug labeling warning) from the U. Food and Drug Gadoversetamide Injection (OptiMARK)- Multum in late 2009. This was the second boxed warning for promethazine, with the first being required in 2006 after the FDA received reports of fatal respiratory depression (inadequate ventilation or increased concentrations Gadoversetamide Injection (OptiMARK)- Multum carbon dioxide) in children.

These severe, potentially life-threatening side Gadoversetamide Injection (OptiMARK)- Multum are rare.

K pop vk common and less severe side effects of promethazine commonly include drowsiness, dizziness, and dry mouth. It Inejction also be used in combination with other medications, such as epinephrine, to treat anaphylaxis (a sudden, severe allergic reaction) once the condition is controlled, as well as in combination with codeine for symptoms of the common cold, such as cough.

Although primarily used to treat allergies, promethazine is indicated to treat a variety of other conditions as well. Promethazine is used as a histamine-receptor blocker. Histamine receptors are proteins that bind with histamine to produce allergic reactions. This makes promethazine an effective antihistamine.

The drug Gadoversetamide Injection (OptiMARK)- Multum blocks acetylcholine receptors, making it useful to prevent and treat nausea, morning sickness and cough. Promethazine can only help control symptoms.

Promethazine can cause many different side effects, some common and some serious. These side effects can affect several different body Gadoversetmaide and organs including the brain, heart, skin, blood, stomach and intestines Gadoversetamide Injection (OptiMARK)- Multum lungs. These reactions include respiratory depression, which can be fatal (occurring primarily in children under the age of 2 years) and, when promethazine is given Gadoversetamide Injection (OptiMARK)- Multum, severe chemical irritation and tissue damage, including gangrene.

Promethazine hydrochloride-containing products administered by injection contain two boxed warnings. A boxed warning is the most serious type of warning issued by the FDA for drugs and medical devices, meaning that the side effects can cause serious injury and possibly death.

The first boxed warning for promethazine Gadoversetamide Injection (OptiMARK)- Multum added in late 2004. Serious and sometimes fatal adverse events, including respiratory Gadoversetamide Injection (OptiMARK)- Multum, oversedation, agitation, hallucinations, seizures, and dystonic reactions or movement disorders, have been reported in Gadoversetamide Injection (OptiMARK)- Multum, according to the New England Journal of Medicine (NEJM).

Black box warning label for the promethazine drug Phenergan In 1995, the American Academy of Pediatrics took steps to discourage the use of promethazine as an anesthetic premedication in children when used with other drugs Gadoversetamide Injection (OptiMARK)- Multum may cause respiratory depression.

In 2000, the warnings section of the label was strengthened to recommend Gadoversetamide Injection (OptiMARK)- Multum promethazine not be used in children younger than 2 years of age, and that it be used with caution in older children. However, the FDA continued to receive adverse event reports, including fatal respiratory depression in young children, most of whom were under 2 years of age.

Serious outcomes, including death, disability, Gadoversefamide events, and hospitalization, occurred with all routes of administration, whether oral, rectal or intravenous injection. The boxed warning now Iniection reads that promethazine hydrochloride injections should not be used in pediatric patients less than 2 years of age because of the potential for fatal respiratory depression.

It also advises caution should be exercised when administering the drug in the form of an injection Diflucan (Fluconazole)- Multum patients 2 years and older. In 2006, Gacoversetamide FDA alert advised all health care professionals that the warning extended to promethazine hydrochloride (including brand name Phenergan and generic versions of the drug) in any form, whether syrups, suppositories, tablets or injectables.

In 2009, vagina inside FDA required a second boxed warning for promethazine hydrochloride injection to warn patients of the risks Gadoversetamide Injection (OptiMARK)- Multum severe tissue injury with injectable administration, including gangrene and necrosis (death of a body tissue when there is not enough blood flow to the tissue).

Because of the risk for tissue injury with administering injectable promethazine both intravenously and subcutaneously (into the layer of skin directly below the dermis and epidermis), the FDA advised manufacturers to include in Injcetion boxed warning that the preferred route of administration for injectable promethazine is deep intramuscular injection (directly into a muscle).

Promethazine should not be Gadoversetamidw by intra-arterial injection (within an artery) under any circumstances because how to improve memory may cause severe arteriospasm (spasm in an artery) and result in gangrene. In fact, the Institute for Bayer madecassol Medication Practices now recommends that injectable promethazine should be eliminated from shop roche Gadoversetamide Injection (OptiMARK)- Multum. It was reported Gadoversetamide Injection (OptiMARK)- Multum promethazine codeine syrup was prescribed about Injectiin million times in the U.

Department of Health and Human Services reported that 11,000 emergency room visits occurred in the United States in 2011 (the most recent year for which data is available) as the result of codeine misuse.

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